Effect of systemic vascular resistance on the agreement between stroke volume by non-invasive pulse wave analysis and Doppler ultrasound in healthy volunteers
Sole Lindvåg Lie, Jonny Hisdal, Marius Rehn, aLars Øivind Høiseth
Abstract
Stroke volume can be estimated beat-to-beat and non-invasively by pulse wave analysis (PWA). However, its reliability has been questioned during marked alterations in systemic vascular resistance (SVR).
Introduction
Reliable measurements of stroke volume are essential for understanding cardiovascular dynamics and assessing hemodynamic changes in both clinical and research settings. Stroke volume estimated by pulse wave analysis (PWA) using the volume-clamp method is non-invasive, user-independent and provides beat-to-beat values for real-time assessment [1].
Materials and Methods
The study was approved by the regional ethics committee (REC South East A, ref. 2017/136). Healthy volunteers > 18 years of age were recruited from November 1, 2017, to June 20, 2018. They provided written informed consent. The exclusion criteria were pregnancy, conditions limiting physical performance or requiring regular medication (except contraceptives) or history of syncope (except presumed vasovagal syncope).
Result
Sixteen subjects (nine females) with age 24 ± 3 years, weight 71 ± 14 kg, height 177 ± 11 cm and body mass index 23 ± 3 kg/m2 participated in this study. All subjects completed LBNP 20, 15 subjects (eight females) completed LBNP 40, 11 subjects (five females) completed LBNP 60 and two subjects (one female) completed LBNP 80.
Discussion
This experimental study in healthy volunteers demonstrated a statistically significant but small effect of SVR on the agreement between SVPWA and SVUS during reductions in stroke volume and increases in SVRUS with LBNP and IHG. The difference between methods was lower when the means of the methods were higher, an effect explained by SVRUS in the regression analysis.
Conclusion
In healthy volunteers, during a combination of LBNP and IHG to reduce stroke volume and increase SVR, the agreement between stroke volume by PWA and suprasternal Doppler ultrasound decreased during increases in SVR.
Citation: Lie SL, Hisdal J, Rehn M, Høiseth LØ (2024) Effect of systemic vascular resistance on the agreement between stroke volume by non-invasive pulse wave analysis and Doppler ultrasound in healthy volunteers. PLoS ONE 19(5): e0302159. https://doi.org/10.1371/journal.pone.0302159
Editor: Farina Binti Mohamad Yusoff, Hiroshima University: Hiroshima Daigaku, JAPAN
Received: October 17, 2023; Accepted: March 27, 2024; Published: May 7, 2024
Copyright: © 2024 Lie et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: The dataset used for the analyses in this publication contains de-identified data. Due to ethical regulations imposed by the hospital's data protection officer restricting the publication of de-identified data, we therefore cannot publish the dataset. However, it may be made available upon reasonable request by contacting the data protection officer at Oslo University Hospital, personvern@ous-hf.no.
Funding: The author(s) received no specific funding for this work.
Competing interests: The authors have declared that no competing interests exist.
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0302159#abstract0
