Prevalence and associated factors of chronic kidney disease among diabetes mellitus patients in Ethiopia: A systematic review and meta-analysis
Habtamu Wagnew Abuhay, Melaku Kindie Yenit, Mihret Melese, Gebrie Getu Alemu, Fantu Mamo Aragaw
Abstract
Chronic kidney disease (CKD) is a major public health concern worldwide, especially among people with diabetes mellitus (DM), which is the main cause of morbidity and mortality. In Ethiopia, the burden of CKD on DM patients is compounded by a variety of socioeconomic and healthcare-related issues.
Introduction
Chronic kidney disease (CKD) is a major global public health concern, affecting about 10% of the global population, or more than 800 million people [1]. The risk is markedly higher in individuals with diabetes mellitus (DM) [2]. If left untreated, CKD results in renal failure and end-stage renal disease (ESRD) [3].
Methods
This systematic review and meta-analysis was registered in the international database of the Prospective Register of Systematic Reviews (PROSPERO) with registration number CRD42024576958.
Results
For this systematic review and meta-analysis, a total of 773 articles were found using various electronic databases. After the initial exclusion of duplicates (280), 493 articles were screened based on the title and abstract. After screening the titles and abstracts, 25 patients were eligible for full-text review.
Discussions
CKD is a significant health concern among patients with DM. It affects millions of individuals globally and contributes to increased morbidity and mortality rates. This systematic review and meta-analysis aimed to estimate the pooled prevalence of CKD among DM patients in Ethiopia and compare it with findings from other regions.
Conclusion
The prevalence of CKD in Ethiopia was high, affecting nearly two in five individuals with diabetes. In addition, factors such as older age, rural residence, longer DM duration, positive proteinuria, lower HDL levels, and a family history of CKD were significantly associated with CKD prevalence.
Citation: Abuhay HW, Yenit MK, Melese M, Alemu GG, Aragaw FM (2025) Prevalence and associated factors of chronic kidney disease among diabetes mellitus patients in Ethiopia: A systematic review and meta-analysis. PLoS ONE 20(3): e0315529. https://doi.org/10.1371/journal.pone.0315529
Editor: Hamidreza Karimi-Sari, Johns Hopkins University School of Medicine, UNITED STATES OF AMERICA
Received: August 24, 2024; Accepted: November 26, 2024; Published: March 5, 2025
Copyright: © 2025 Abuhay et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: All data relevant to the study are included in the article or uploaded as supplementary information.
Funding: The author(s) received no specific funding for this work.
Competing interests: The authors have declared that no competing interests exist.
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0315529#abstract0
