Relationship between body mass index and clinical events in patients with atrial fibrillation undergoing percutaneous coronary intervention
Tatsuro Yamazaki, Hideki Kitahara, Daichi Yamashita, Takanori Sato, Sakuramaru Suzuki, Takashi Hiraga, Tadahiro Matsumoto, Takahiro Kobayashi, Yuji Ohno, Junya Harada, Kenichi Fukushima, Tatsuhiko Asano, Naoki Ishio, Raita Uchiyama, Hirofumi Miyahara, Shinichi Okino, Masanori Sano, Nehiro Kuriyama, Masashi Yamamoto, Naoya Sakamoto, Junji Kanda, Yoshio Kobayashi.
Abstract
It is still unclear whether body mass index (BMI) affects bleeding and cardiovascular events in patients requiring oral anticoagulants (OAC) for atrial fibrillation (AF) and antiplatelet agents after percutaneous coronary intervention (PCI) for coronary artery disease (CAD).
Introduction
Body mass index (BMI), calculated as body weight in kilograms divided by height in meters squared, is a common and simple indicator, which can evaluate physique easily in daily clinical practice. In general, patients with a high value of BMI are likely to have chronic diseases associated with progression of arteriosclerosis, such as diabetes, hypertension, and dyslipidemia [1, 2].
Materials and methods
This was a multicenter and observational cohort study performed in 15 hospitals in Japan (CHIBA AF-PCI registry) [20]. The study flow is summarized in Fig 1.
Results
In a total of 720 patients enrolled, the first quartile value of BMI was 21.3 kg/m2, and based on this value, patients were divided into the Group 1 (n = 180) and Group 2 (n = 540) groups. Baseline characteristics are shown in Table 1.
Discussion
In the present study, patients in the Group 1 had a higher risk of NACE and MACE, and BMI value <21.3 kg/m2 was independent predictor for NACE and MACE within 1 year after performing PCI in patients under OAC therapy for AF. On the other hand, BMI value <21.3 kg/m2 was not significantly associated with major bleeding events.
Conclusions
Among the patients undergoing PCI for CAD and requiring OAC for AF, low BMI value was independently associated with the incidence of NACE and MACE, although not with the incidence of major bleeding events.
Citation: Yamazaki T, Kitahara H, Yamashita D, Sato T, Suzuki S, Hiraga T, et al. (2024) Relationship between body mass index and clinical events in patients with atrial fibrillation undergoing percutaneous coronary intervention. PLoS ONE 19(9): e0309758. https://doi.org/10.1371/journal.pone.0309758
Editor: Yoshihiro Fukumoto, Kurume University School of Medicine, JAPAN
Received: June 1, 2024; Accepted: August 18, 2024; Published: September 19, 2024
Copyright: © 2024 Yamazaki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: All relevant data are within the manuscript and its Supporting Information files.
Funding: The author(s) received no specific funding for this work.
Competing interests: The authors have declared that no competing interests exist.
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0309758#abstract0
