Research Insights
This section focuses on the most recent research and discoveries across the globe in the various healthcare disciplines.
Masticatory dysfunction in patients with diabetic neuropathy
Chewing well is essential for successful diet therapy and control of blood glucose level in patients with diabetes In addition longterm hyperglycemia is a risk factor for microvascular complications which are the main cause of morbidity and mortality in these patients Hence it is plausible that masticatory disorder may be relevant to diabetic micro...
Changes in dynamics of tumor/endothelial cell adhesive interactions depending on endothelial cell growth state and elastic properties
Cancer cell adhesion to the endothelium is a crucial process in hematogenous metastasis but how the integrity of the endothelial barrier and endothelial cell EC mechanical properties influence the adhesion between metastatic cancer cells and the endothelium remain unclear In the present study we have measured the adhesion between single cancer cell...
Surgeons’ preferences for using sentinel lymph node biopsy in patients with ductal carcinoma in situ
There is a large variation between Dutch hospitals in the use of Sentinel Lymph Node Biopsy SLNB in patients with a biopsy diagnosis of Ductal Carcinoma in Situ The aim of our study was to investigate whether this variation might be explained by preferences of surgeons organisational factors or the influence of patients preferences
Evaluation of quantitative accuracy among different scatter corrections for quantitative bone SPECT/CT imaging
Although scatter correction improves SPECT image contrast and thus image quality the effects of quantitation accuracy under various conditions remain unclear The present study aimed to empirically define the conditions for the optimal scatter correction of quantitative bone SPECTCT images Scatter correction was performed by applying
Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC–WHO clinical ch
Acute kidney injury AKI is one of the most common and significant problems in patients with Coronavirus Disease COVID However little is known about the incidence and impact of AKI occurring in the community or early in the hospital admission The traditional Kidney Disease Improving Global Outcomes KDIGO definition can fail to identify patients for...
Brain-based measures of nociception during general anesthesia with remifentanil
Catheter radiofrequency RF ablation for cardiac arrhythmias is a painful procedure Prior work using functional nearinfrared spectroscopy fNIRS in patients under general anesthesia has indicated that ablation results in activity in painrelated cortical regions presumably due to inadequate blockade of afferent nociceptors originating within the cardi...
Effect of glutamate infusion on NT-proBNP after coronary artery bypass grafting in high-risk patients (GLUTAMICS II): A randomized controlled trial
Animal and human data suggest that glutamate can enhance recovery of myocardial metabolism and function after ischemia Nterminal probrain natriuretic peptide NTproBNP reflects myocardial dysfunction after coronary artery bypass surgery CABG We investigated whether glutamate infusion can reduce rises of NTproBNP in moderate to highrisk patients afte...
Antibody responses against SARS-CoV-2 variants induced by four different SARS-CoV-2 vaccines in health care workers in the Netherlands
Emerging and future SARSCoV variants may jeopardize the effectiveness of vaccination campaigns Therefore it is important to know how the different vaccines perform against diverse SARSCoV variants As of March the coronavirus disease COVID pandemic has caused over million confirmed infections
