Research Insights
This section focuses on the most recent research and discoveries across the globe in the various healthcare disciplines.
Association Between Intraoperative End-Tidal Carbon Dioxide and Postoperative Organ Dysfunction in Major Abdominal Surgery: A Cohort Study
Data on the effects of intraoperative endtidal carbon dioxide EtCO levels on postoperative organ dysfunction are limited Thus this study was designed to investigate the relationship between the intraoperative EtCO level and postoperative organ dysfunction in patients who underwent major abdominal surgery under general anesthesia
Optimizing Cardiovascular Risk Assessment and Registration in a Developing Cardiovascular Learning Health Care System: Women Benefit Most
Since we organized a uniform structured collection of a fixed set of cardiovascular risk factors according the international guidelines on cardiovascular risk management We evaluated the current state of a developing cardiovascular towards learning healthcare systemthe Utrecht Cardiovascular Cohort Cardiovascular Risk Management
Automated Large-scale Prediction of Exudative And Progression Using Machine-read Oct Biomarkers
Agerelated Macular Degeneration AMD is a major cause of irreversible vision loss in individuals over years old in the United States One of the latestage manifestations of AMD and a major cause of vision loss is the development of exudative macular neovascularization MNV Optical Coherence Tomography OCT is the gold standard
Sensor-based Telerehabilitation System Increases Patient Adherence After Knee Surgery
Implementing evidencebased recommendations with the option of patientindividualised and situationspecific adaptations in telerehabilitation may increase adherence with improved clinical outcome We here present three different perspectives of the first DMD for knee rehabilitation First we sought to determine the usage patterns
The discrepancies between clinical and histopathological diagnoses of cardiomyopathies in patients with stage D heart failure undergoing heart transplantation
This study aimed to determine the etiology of stageD heart failure HF and the prevalence and prognosis of misdiagnosed cardiomyopathy in patients undergoing heart transplantation Heart failure is a common clinical syndrome caused by various cardiovascular diseases Evaluation of heart failure etiology
A scoping review of randomized trials assessing the impact of n-of-1 trials on clinical outcomes
The single patient nof trial can be used to resolve therapeutic uncertainty for the individual patient Treatment alternatives are systematically tested against each other generating patientspecific data used to inform an individualized treatment plan We hypothesize that clinical decisions informed by nof trials improve patient
Masticatory dysfunction in patients with diabetic neuropathy
Chewing well is essential for successful diet therapy and control of blood glucose level in patients with diabetes In addition longterm hyperglycemia is a risk factor for microvascular complications which are the main cause of morbidity and mortality in these patients Hence it is plausible that masticatory disorder may be relevant to diabetic micro...
Changes in dynamics of tumor/endothelial cell adhesive interactions depending on endothelial cell growth state and elastic properties
Cancer cell adhesion to the endothelium is a crucial process in hematogenous metastasis but how the integrity of the endothelial barrier and endothelial cell EC mechanical properties influence the adhesion between metastatic cancer cells and the endothelium remain unclear In the present study we have measured the adhesion between single cancer cell...
Surgeons’ preferences for using sentinel lymph node biopsy in patients with ductal carcinoma in situ
There is a large variation between Dutch hospitals in the use of Sentinel Lymph Node Biopsy SLNB in patients with a biopsy diagnosis of Ductal Carcinoma in Situ The aim of our study was to investigate whether this variation might be explained by preferences of surgeons organisational factors or the influence of patients preferences
Evaluation of quantitative accuracy among different scatter corrections for quantitative bone SPECT/CT imaging
Although scatter correction improves SPECT image contrast and thus image quality the effects of quantitation accuracy under various conditions remain unclear The present study aimed to empirically define the conditions for the optimal scatter correction of quantitative bone SPECTCT images Scatter correction was performed by applying
